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UCLA in Denial over Philip Morris Funded Research
February 26, 2008

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Commentary
by Steve Heilig

Last week I was sitting in one of San Francisco's blissfully smoke-free cafes and found a discarded copy of the Los Angeles Times. (We don't often see that fine paper here in our much more refined city.) So I leafed through it and came upon a story titled: "A smoldering controversy at UCLA; The school accepts money from tobacco giant Philip Morris in its three-year study of nicotine addiction. Teenagers and monkeys are part of the research" (Los Angeles Times, Feb. 9).

As an otherwise proud graduate of the UCLA School of Public Health and longtime anti-tobacco advocate, that headline certainly caught my attention. The well-written article focused not only on the controversy over Philip Morris funding but also on "animal rights" protests and issues, as activists had targeted the researcher's house. That's very unfortunate. As someone who has been "stalked" by self-proclaimed activists who have opposed my work on abortion and yes, drug abuse topics, I do know how that feels - unnerving, at a minimum. So I feel for Edythe London, a respected professor of psychiatry and pharmacology. Violence and vandalism are indefensible.

But I must also respectfully observe that London, presumably something of an expert on the human brain and emotions, may be participating in a strong bit of willful denial about her own work. Philip Morris awarded her and UCLA $6 million for her research, and UCLA officials admit "the idea for the study of teenagers and monkeys originated with Philip Morris."

Then comes this astounding quote: "Roberto Peccei, vice chancellor for research at UCLA, said the company's motives were immaterial. 'I have no idea why Philip Morris decides to fund this anti-smoking research, but they do,' he said. 'As long as we do not feel that we are interfered with and that the research is done with the highest intentions, what's in the mind of the funder is irrelevant'."

Well. Such a statement could have been made with some validity - due to lack of information - a generation or so ago. Now we know, from decades of research and disclosure of tobacco industry documents, that the source of funding and motives make a huge difference - not just with regard to tobacco but in other arenas as well, such as pharmaceuticals, industrial chemicals, and more. The differences come in terms of outcome of the actual research, behavior of clinicians and others who read and are influenced by it, marketing activities of the profit-motivated funders, and more.

These influences are found even when there is no outright mention of the funder's name - that's one of the funny little mysteries of human motivation and the altering of it, and the tobacco and other industries seem to know as much or more about that than anyone else.

This is why, after numerous embarrassments, most leading scientific and medical journals have adopted much stricter "conflict of interest" disclosure policies, with source of funding for research being the main reason for that.

It's also why a rapidly growing number of professional schools and entire universities also have stricter policies, including many banning such funding outright. Major medical organizations such as Kaiser Permanente ban pharmaceutical sales representatives and funding as they recognize even the "educational" and "research" efforts of industry as just what it is - marketing.

Thus, knowledgeable readers of the journals almost wholly discount papers published where the funder in question has a clear conlfict - and as a reviewer for such journals, and editor of one, I vote to not even publish such tainted research, at least not without prominent disclaimers and even cautionary commentary. That's a shame where, as in this case, "clean" research might well have yielded some important and even life-saving information. As things now stand, if this research looks promising, it's likely somebody with higher ethical standards will have to replicate it in order for it to be more widely accepted.

Philip Morris "has no intention of using the results or teenagers' brain scans to develop more addictive cigarettes", according to their spokesman in the LA Times story. "We would never do that," he said. Long and lethal evidence proves otherwise. UCLA researchers and officials should know this, and act accordingly.

But as the evidence shows, money can buy just about anything, including denial. I well recall how Philip Morris "research" was used to fight our pioneering effort to ban smoking in the very types of café where I came across the newspaper that contained this sad, disturbing story.

Steve Heilig
San Francisco, CA
Editor, Cambridge Quarterly of Healthcare Ethics

Join Together publishes selected commentary relevant to alcohol and drug policy, prevention and treatment. The views expressed are solely those of the author.

COMMENTS ON THIS ARTICLE:

Posted by Barry McMillen, MA, CTAS on 27 Feb 08 09:57 AM EST
I am amazed at the foolishness of UCLA officals. The well documented unethical behavior of the Tobacco Cartel appears to extend to the "anything for money" mentality of UCLA's chancellor of research. I am further shocked by the statement of the belief that the Tobacco Cartel will not use any of the research results to further their addiction of American youth. I must restrain myself as I have, before this anyway, expected more from those who proclaim to have a higher goal to teach. So much for American values, for some that is.

Posted by Dave on 27 Feb 08 10:56 AM EST
Steve Heilig's point that the UCLA research is automatically tainted by the funding source seems irrational. The reasonable question would be: can unbiased valid research be conducted when money for the research is provided by people who have an interest in the outcome. I would think that if the money is provided without strings, conducted according to accepted standards and performed by researchers committed to accepting any outcome suggested by the data, the answer would be, "Yes, of course, the research can be valid." I think to automatically judge the validity of research by the funding source is categorical thinking unworthy of scientists. A scientist looks at all factors and then learns what she can from the data. Consequently, I would agree with Dr London that we should wait for the study's results and then evaluate it with the funding source in mind.

Posted by Steve Heilig on 29 Feb 08 11:47 AM EST
Thanks for the comments. Re Dave's - you are correct that it's an "irrational" dynamic, and in fact, that's the underlying point. In pharmaceutical marketing, there are increasing restrictions on what drug companies can do, so that often their products and even their name cannot be mentioned in "educational" and other programs they sponsor. But they still are eager to sponsor - with "no strings" - as they know the literature which shows that even only giving a subsidy subtly influences MD proscribing behavior (which, again, is why many hospitals, med schools, and health systems now prohibit even "no strings" pharma sponsorship). Big Tobacco knows this too - remember, the study in question was Philip Morris's idea! And, just as bad, as Barry McMillen notes, chances are very good that they seek to use whatever results in a most unhealthy manner - not what the researchers intended, of course, but not something they will then be able to stop, either. I am glad to see there is now some legislative activity brewing, looking into this sad breach of current research standards. I still sadly believe UCLA has been conned. SH

Posted by Steve Heilig on 03 Mar 08 12:58 PM EST
One more item - a timely update: Philip Morris Ends 8-year Academic Research Program Philip Morris, the largest tobacco-industry sponsor of American academic studies, has ended an eight-year program that funded university research across the country, Science reported . However, anti-tobacco researchers warn the industry will likely continue to fund academic research through other channels. The Philip Morris External Research Program (PMERP) supported 470 research proposals from 60 medical schools over the eight years. Launched in 2000, PMERP had been criticized as an extension of Philip Morris research programs launched to cast doubt on the dangers of smoking. Although researchers on the Philip Morris dole learned in September of 2007 that PMERP was ending, the company’s decision only came to light through a letter from University of California (UC) President Robert Dynes to UC chancellors. Dynes reminded the chancellors at each of the university’s 10 campuses to closely monitor research funding from tobacco companies to comply with new guidelines prohibiting tobacco industry research support. In 2006-2007, the University of California campuses received 23 grants from Philip Morris that totaled to $16 million. Meanwhile, Stanton Glantz, a UC San Francisco professor and long-time anti-tobacco advocate, warned that the tobacco industry will continue to impact academic research. Glantz cited Edythe London, a UC Los Angeles researcher who received a $6 million grant from Philip Morris to study addiction as evidence that tobacco-industry funded research at American universities will continue long after PMERP ends.

Posted by Peter O'Loughlin on 03 Mar 08 02:03 PM EST
It seems to this writer that the hysterical reaction of the anti smoking lobby is determined to block any research that might, just might, show that any of the evidence they have used in order to deny nicotine addicts their right to continue the consumption of a legal drug, is flawed. To accuse anyone of an offence prior to conclusion of researched evidence is an indicaion of a completely closed and prejudiced mind. However this is not the first time that the anti smoking lobby has sought to block evidence that threatens their views, and I dont suppose it will be the last. By the way has anyone got any empirical evidence of deaths where the cause is recorded as death from passive smoking? As for death from smoking itself, here in the UK 130,000 smoking related deaths were recorded for 2006-7, horrifying as that is, given that we have some 20 million smokers, it is a very small percentage.

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