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Cocaine Changes in Brain Reversed by Amino Acid, Animal Study Suggests
October 26, 2009

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Research Summary

Researchers from the Medical University of South Carolina say that a common amino acid could be used to undo the brain-circuitry changes wrought by cocaine use and reduce craving for the drug, Science Daily reported Oct. 23.

"Our finding suggests a promising therapeutic strategy for cocaine addiction, for which there is no approved treatment," said lead researcher Khaled Moussawi.

Moussawi and colleagues administered the amino acid N-acetlycysteine (NAC) to lab rats addicted to cocaine and found that the rats stopped seeking drugs, even when given drug-associated cues. NAC is involved in the pathway for the neurotransmitter glutamate.

The study findings were unveiled at the recent annual meeting of the Society of Neuroscience.

COMMENTS ON THIS ARTICLE:

Posted by Pat on 27 Oct 09 09:29 AM EDT
Are there any side effects or major drug interactions associated with NAC since it an amino acid and can be purchased OTC? Or are they speaking of a stronger form that would require a prescription?

Posted by Lisa Frederiksen on 27 Oct 09 11:49 AM EDT
This is exciting -- as is what it could mean for treating the cravings of other addictions as well!

Posted by Colleen on 27 Oct 09 11:58 AM EDT
No major side-effects. The reason for NAC are that after long-term exposure to cocaine, as well as a few other drugs of abuse, is that the cysteine-glutamate exchanger protein on astrocytes near the nucleus accumbens loses its homeostasis, resulting in a depletion of cysteine with a constant influx of glutamate.

Posted by anna corum on 29 Oct 09 12:05 AM EDT
This sounds so promising, would be like a miracle,God help this to be real. So many need help, please keep us informed of new or any development. AC

Posted by Rajiv Bhole on 02 Nov 09 12:07 PM EST
NAC is a powerful antioxidant. It combines with amino acids glutamine/glutamate and glycine to form glutothione the most powerful natural antioxidant found in all living organisms. It has been known to fight addictions, even gambling addiction. But to stop cocaine addiction the amino tyrosine is the best, not just NAC. Scientist and researchers have known it for years but the pharmaceutical and medical industry, and health care providers, have seen to it that the information does not reach the common man. They can't patent amino acids and vitamin, you see. And the medical industry makes over half a trillion dollars each year by seeing to it that the addict don't get cured. Addictions can be cured by merely using nutrition supplements. Do read the books like 'End your Addiction Now' by Charles Gant or 'The Vitamin Cure for Alcoholism' by Abram Hoffer to find out which perticular amino acids and vitamin definately cure addictions to heroin, coke, sedatives, nicotine and alcohol. I hope this information reaches the addicts soon.

Posted by Dr. John on 03 Nov 09 03:31 PM EST
There have been many very bright and talented researchers and clinicians over the years who have explored the use of amino acids in the treatment of addictive disorders. It has always amazed me that their research and clinical practice (Blum, Hitt, Mathews-Larsen, etc.) has not resulted in more widespread examination. But then, there's not a lot of money in amino acids, is there?

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