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Marijuana May Slow Memory Loss Among Elderly
December 1, 2008

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Research Summary

New research from Ohio State University suggests that small, daily doses of marijuana may slow the onset of memory loss and diseases like Alzheimer's, Parkinson's and multiple sclerosis, the Toronto Globe and Mail reported Nov. 20.

Researchers gave rats affected by memory loss small doses of a synthetic compound identical to THC, the main ingredient in marijuana, to activate areas in the brain affected by memory loss. They found that giving the rats the equivalent of one puff of marijuana -- not enough to get high -- activated these brain regions and stimulated new brain-cell formation.

The rats were exposed to the drug, WIN-55212-2, for three weeks, after which the researchers assessed the rats based on a memory test. The rats treated with the compound performed better on the test than those not given the drug, the study authors found. The experimental group also experienced reduced inflammation and more growth of new brain cells.

"We are trying to tease out the positive aspects of this plant," said researcher Gary Wenk, professor of psychology and neuroscience at Ohio State University. "Millions of people have used this plant for thousands of years. There is a lot of evidence that there are some interesting things going on in the brains of these people."


The researchers said they are hopeful that their research may lead to the development of a drug to slow down memory loss in those with a history of degenerative disease in their families. "The model could be used for anyone at risk," added Yannick Marchalant, co-author of the study, "perhaps 20 years before the usual onset of the decline in memory."

The researchers presented their findings at the annual meeting of the Society for Neuroscience.

This article summarizes an external report or press release on research published in a scientific journal. When available, links to the sources are provided above.

COMMENTS ON THIS ARTICLE:

Posted by Dave on 02 Dec 08 09:43 AM EST
Interesting considering that one of the most reliable results of heavy marijuana use is short term memory loss. This is reminiscent of the research on nicotine's effect on early dementia. There are studies going in both directions: that exposure to tobacco smoke increases the likelihood of developing dementia and also that it can delay the progression of dementia. At this point, it's premature to make any suggestions except that we need further research. However, the Globe article (at least what's available without paying for a subscription) seems to be enthusiastically advising people about marijuana to "get by with a little help from my friends".

Posted by brubin on 02 Dec 08 11:56 AM EST
what dave is not paying attention to is the dosage!it has been proven that several glasses of wine or hard liquor are good for the heart and circulatory system. 50 glasses will destroy your liver and brain cells.dosage,dosage and dosage!

Posted by rachelrachel on 03 Dec 08 12:38 AM EST
brubin: If you drink "several glasses of wine or hard liquor" on a single occasion, you are binge drinking. It is almost certainly bad for you. If you do this often, it is very, very, bad for you. There are some studies that show a reduced rate of coronary heart disease for "moderate" drinkers compared to nondrinkers or to heavier drinkers. However, if you drink enough to get this cardiovascular protective effect, you are also putting yourself at risk for numerous other problems, such as several forms of cancer, hemorrhagic stroke, brain shrinkage, liver disease. Most of these effects are small, but the cardioprotective effect is also small. Whether there's a net benefit in a daily drink or two is a hotly debated topic. But if you go above that drink or two per diem, the associated health risks climb upwards. Back to the pot thing, the researcher. Dr. Marchalant, says he hopes we can develop a drug that can stave off the memory loss. He is not suggesting that people take a daily bong hit. The Globe and Mail writers seemed to be looking for a headline that grabbed the reader's attention, in this case at the cost of being accurate.

Posted by caitlinr@stonehillcollege on 04 Dec 08 09:04 AM EST
Because of the sensitivity surrounded by both the issue of marijuana and the diseases mentioned in the opening paragraph (Alzheimer's, Parkinson's and multiple sclerosis), I believe MUCH more research needs to be done expanding on this study before making any definite claims. While the initial research does sound exciting and promising, the brains of people with memory loss and severe diseases are very different than those of rats. Researchers should see the results of using this drug in clinical trials with patients in varying stages of the mentioned diseases. However, one must also ask if this drug is synthetically identical to THC (which is also said to help cancer patients) if it will undergo the same medical restrictions and controversy as medical marijuana.

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