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DrugScreening.org


 

Buprenorphine Beats Naltrexone in Heroin Treatment, Study Says
July 2, 2008

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Research Summary

Opiate addicts given the anti-addiction medication buprenorphine -- an alternative to methadone maintenance -- were twice as likely to remain abstinent and half as likely to relapse as patients taking naltrexone, an opioid receptor antagonist, researchers say.

All Headline News reported June 26 that researcher Richard Schottenfeld of Yale University and colleagues compared the effectiveness of the two drugs on 126 patients in Malaysia over a 22-month period, using a placebo-controlled double-blind trial.

The researchers concluded by endorsing buprenorphine but not naltrexone as part of opiate treatment.

The study appears in the June 28, 2008 issue of the journal Lancet.

This article summarizes an external report or press release on research published in a scientific journal. When available, links to the sources are provided above.

COMMENTS ON THIS ARTICLE:

Posted by Ron Ferguson, CBT on 08 Jul 08 04:12 AM EDT
While I concede that the buprenorphine maintenance concept has shown limited success in studies such as the one in this article, I believe that it is largely ineffective as a treatment for opiate dependence. That is, of course, unless we are willing to admit that by "maintenance" we are merely assisting the addict in maintaining his addiction. The only proven treatment of opiate dependence is that of behavior modification, and the first behavior that must be modified is that of drug use. The addict must abstain from the ingestion of drugs before we can successfully address the underlying issues of dependence. The opioid antagonist and agonist should be limited to the 14-day period of detox, and then only in a gradually declining dosage. The ultimate goal must be to eliminate daily dependence on substance use in a most immediate manner.

Posted by John French on 03 Jul 08 04:06 PM EDT
My guess is the most meaningful outcome of this study was that two Yale profs got a trip to the Far East and another article under their belt. Lets hope their next head-to-head has more worth, like maybe buprenorphine vs methadone. Oops, that one has been done, too. Methadone comes out ahead, but buprenorphine is more convenient for those who can pay for it.

Posted by Robert Curley, News Editor, Join Together on 03 Jul 08 03:18 PM EDT
Technically, it's a report on a report about the report. Seriously, however, Join Together simply does not have the resources to be reading and reviewing journal articles, a task that would take far longer than summarizing news stories. It is partly for this reason that we provide links to the primary source material whenever it is available. The hotlink to the Lancet in the above summary will take you directly to the abstract of the Yale study so you can read it and draw your own conclusions about the study.

Posted by Perry Kaplan on 03 Jul 08 09:09 AM EDT
Good idea, but you should be reviewing the Lancet article and providing more detail on results, rather than reporting on a report about an article written about a report on the subject.

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