The DEA said that the sole government-licensed marijuana farm, at the University of Mississippi, grows a "sufficient quantity and quality" of marijuana for research.

But Dr. Lyle Craker, a professor of plant biology at UMass who applied for the license, said researchers have criticized the government's marijuana as being too weak. They also complained of difficulties in obtaining permission to use it.

"We wanted to have a source independent from the government and with a known potency so doctors can run clinical trials," said Craker.

A DEA spokeswoman said the agency has no comment on its decision. The university has 30 days to appeal.

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