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French Doctor Says Baclofen Cures Addiction
December 10, 2008

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French cardiologist Oliver Ameisen is urging researchers to conduct clinical trials testing the effects of baclofen, a muscle relaxer that Ameisen says can cure alcohol and cocaine addictions, the BBC reported Dec. 6.

After reading that baclofen seemed to alleviate rats' alcohol and cocaine addictions, Ameisen began self-medicating with the drug in 2002 to treat his alcoholism. Ameisen continues to take daily doses of the drug today, and describes its positive effects in his book, "The Last Glass" (Le Dernier Verre), which reached best-seller status in France this fall and will be published in English next month.

"Mine is the first case in which a course of medicine has completely suppressed alcohol addiction," said Ameisen. "Now I can have a glass and it has no effect. Above all, I no longer have that irrepressible need to drink."

The book has sparked interest from many to begin baclofen treatment, but the drug has not been approved to treat alcoholism. "We need comprehensive tests to determine how this drug acts, if it is effective and at what dosage, and if it is genuinely harmless in the longer term," said Alain Rigaud, president of France's National Association for the Prevention of Alcoholism and Addiction. "But even if it turns out to work, that does not mean a drug alone is the solution."

However, other doctors report positive results with prescribing baclofen to treat addiction. "I have never had reactions like this before," said Pascal Garche, a physician in Geneva, Switzerland, who found that seven out of his 12 patients who he put on baclofen reported improvements. "We cannot ignore findings such as this.

COMMENTS ON THIS ARTICLE:

Posted by alexgb on 11 Dec 08 10:04 AM EST
Great! But Dr. Ameisen will need to watch those pesky withdrawal symptoms - which "may include auditory hallucinations, visual hallucinations, tactile hallucinations, delusions, confusion, agitation, delirium, disorientation, fluctuation of consciousness, insomnia, inattention, memory impairments, perceptual disturbances, anxiety, depersonalization, hypertonia, hyperthermia, formal thought disorder, psychosis, mania, mood disturbances, restlessness, and behavioral disturbances, tachycardia, seizures, tremors, autonomic dysfunction, hyperpyrexia, extreme muscle rigidity resembling neuroleptic malignant syndrome and rebound spasticity" (citing wikipedia)

Posted by Jerry on 11 Dec 08 10:35 AM EST
The majority of folks detoxing from alcohol are able to do so with no or very little medication. Very few that I have dealt with have had any of the symptoms alluded to in the previous comment. If Baclofen offers hope for some, then we should give it more consideration. Over the years the treatment profession and researchers have spent an enormous amount of time doing exactly what we tell our clients/patients/customers not to do. And that is; "Don't complicate a simple process".

Posted by Anonymous on 11 Dec 08 11:58 AM EST
Medication can alleviate some cravings and help reduce relapse risk. But the relational aspects of addiction will never be addressed by any medication.

Posted by Tiffany on 11 Dec 08 02:38 PM EST
Since when is self-medicating to treat addiction new?? I am thankful Alain Rigaud, president of France's National Association for the Prevention of Alcoholism and Addiction has the knowledge that this disease is rarely about just quitting drinking or using drugs!!

Posted by Anonymous on 11 Dec 08 02:41 PM EST
"Ameisen began self-medicating with the drug" - That isn't new!! I am just thankful that Alain Rigaud, president of France's National Association for the Prevention of Alcoholism and Addiction understands that this disease is rarely just about quitting drinking or using mood altering chemicals.

Posted by A.R. Doyle, M.D. on 11 Dec 08 02:56 PM EST
Am I reading it right? "Now I can have a glass [of alcohol?] and it has no effect."

Posted by Rick Treleaven, LCSW on 11 Dec 08 06:29 PM EST
Every few years someone comes out with a "miracle" cure for addiction. Dr. Ameisen has produced the latest in a long string of such cures. The treatment field needs to remain very skeptical until we see some proper research and it is replicated. Until then all Dr. Ameisen deserves is a hearty "Whatever!"

Posted by dgbeaupre on 12 Dec 08 10:53 AM EST
With just this small bit of information, I at once thought, "How unique". One of, "us" trying to figure out a way to drink safely. By using a pill. With some pretty potential nasty side effects. (But you don't understand, I can still DRINK!) As a long-time recovering person and Addictions Professional, I recognize that I can only speak for myself...and when I think of(romanticize!) the possibility of "social" drinking I have to laugh. Even if alcohol had little or no effect on me, my brain is wired to chase the high. Why bother?

Posted by cornelia de marchi on 15 Dec 08 07:18 AM EST
I gave baclofen to some alcoholic patients of mine and my CGI (clinical global impressions) is that it works: I think that it i worth of studying how it is working.

Posted by John French on 15 Dec 08 08:26 AM EST
The alcoholics wildest dream and worst nightmare, rolled into one. He can drink -- and it has no effect.How, long, I wonder, before he stops taking the daily pill, justifying it on the basis of negative side effects.

Posted by SobrietyRocks on 15 Dec 08 08:28 AM EST
Shame on him for encouraging the thought that a cure can be found in a pill!

Posted by Dean H., LCAS, CCS on 15 Dec 08 10:14 AM EST
Dr. Ameisen has asked for clinical trials to test his personal observations. Let's wait and see what the research produces. Meanwhile, consider the breadth of the psychiatric/biologic brain functions that baclofen would need to 'repair' in order to deliver a cure. May these noticable effects be more about drug replacement therapy, i.e., similar to methadone? Wonder what happens if/when one ceases the baclofen therapy?? Wouldn't a 'cure' suggest that we'd see no noticable subsequent withdrawal? Whether cure or reliable treatment, if confirmed, this could be a good contribution to the body of knowledge; a step closer also to a way of limiting the damages of this complex illness.

Posted by alexgb on 15 Dec 08 11:59 AM EST
> "Wonder what happens if/when one ceases the baclofen therapy?? Wouldn't a 'cure' suggest that we'd see no noticable subsequent withdrawal?" See my initial post on this article. That is a list of the symptoms of withdrawal from baclofen. If I take this drug and drink alcohol on top of it, what sort of health care is that? I guess if France wants to take a closer look, that's fine, but I sure don't want my tax dollars researching how relaxing the muscles of an alcoholic allows them to keep drinking because they are on a drug whose withdrawal is worse than the one we are supposedly "treating." This is Alice in Wonderland stuff.

Posted by John on 15 Dec 08 12:22 PM EST
I wonder how reliable his subjective reporting actually is? When self delusion and justification are hallmarks of the disease this has to be noted. I wish he would have explained his statement" Now I have a glass and there is no effect"-no effect in what way? Why, if it is a cure for withdrawls, does he continue to take balclofen, so he can continue to drink? Does it prevet seziures etc.? Small study(one guy!!)-very few verifiable facts.

Posted by qkruse on 15 Dec 08 01:39 PM EST
If it tests out it will be a welcome tool for some who are so severely addicted that they do not seem to be able to to get sober and will die otherwise. It is certainly true that a pill will not treat the ism of alcoholism, and it will not protect the organs should the subject chose to continue to drink...ahem...socially.

Posted by Henry Steinberger from Madison WI on 15 Dec 08 01:49 PM EST
Naltrexone has also been found to take away the high from drinking and many folks don't want to drink without getting high. If this works for some people, that should be fantastic. I saw nothing suggesting that it promotes drinking in this article. The doctors say it worked. Many meds are found to work in Europe and come slowly to the US. I am concerned about the obvious powerful bias against anything that is different or offers hope. Perhaps this will help those folks for whom the usual "treatment" does not work. For the sake of humanity people, please at least keep an open mind until we have all the facts.

Posted by shame-on-who? on 15 Dec 08 02:20 PM EST
Why would anyone say: Shame on you for suggesting a pill can cure a disease. If alcoholISM IS a disease, then why can't there be a cure? Just as some in the deaf community oppose choclear implants to "cure" deafness and remove people from the "deaf community," so too the "Recovery community" needs to keep people sick and stigmatized as "alcoholics" to keep them in the Recovery Community. Hence stopping drinking isn't enough, moving on in life is heresy, a pill that allows one to stop drinking or stop addictive, dependent or abusive drinking is not a cure? If the problem returns when one stops taking a medication, then it's not helpful? Insulin therapy is not a cure for diabetes, but it sure helps. Isn't it OK to find something that helps, lessens harm, leads to a life outside of "recovering"? I'm please with progress - especially if it "cures" the feeling of need to drink. How would this support harmful drinking? The doctor said he could have a glass without having another, but he didn't express the desire to do so. This shame is like a flame.

Posted by Mark Young on 15 Dec 08 02:51 PM EST
The Doctor proposes study. But how would one execute a study of diagnosed alcohol dependent people, and stay within ethical principles? There is a risk-reward balance here which may suggest that even if this drug occasionally works it is not worth the risk. There was a time in 19th Century America when morphine was the curative for alcoholism. Apparently the suggestion of abstinence from a substance as a remedy is horrifying to some, who must consider drinking a prerequisite of living.

Posted by Gayle on 16 Dec 08 04:08 PM EST
Every so many years someone comes up with a new way for alcoholics to drink safely. I thought that argument was over years ago! This is such a dangerous belief! Also, why drink alcohol if it has no effect? Just drink water or soda if that's the case. I believe that we must remain open to new treatment options, but I don't think that's what this is. It doesn't sound like it to me anyway. But, anything that can stop alcoholics from suffering is worth a look.

Posted by carolr on 12 Jan 09 01:11 PM EST
Being relatively new to the ReHab community (as the mother of a person suffering from the horrors of alcohol addiction), I am shocked that anyone would quible over whether this might be a cure or a treatment (if either). If indeed studies show this drug could improve the terrible recovery statistics coming out of the ReHab structure in this country. Many who have had their lives destroyed by addiction would gladly trade that addiction for other side effects. Some of the comments above reek of the moralism I thought that,through research, we had finally come to realize has nothing to do with addiction. We've come a long ways from the "stiff upper lip" approach to depression; why can we not make faster progress on addiction - does the ReHab community have too much vested interest to be open to research that might help millions of people? Are the people who succeeded at the "hard way" to recovery really going to begrudge future generations from being able to do it differently? Please use my tax dollars for fast, exhaustive research on treating, curing, and preventing this devastating disease.

Posted by jerryv on 14 Jan 09 09:50 AM EST
A study has already ready been conducted, results not yet released: http://clinicaltrials.gov/ct2/show/NCT00525252?cond=%22Liver+Diseases%2C+Alcoholic%22&rank=9

Posted by Proud OG on 14 Jan 09 12:24 PM EST
My 58 year old brother suffers from alcoholism and has a future so dim because of his addiction he'd be willing to try Baclofen yesterday. As a personal observer and sideline victim of his current ill, I'd support his decision to try Baclofen immediately, an action that delivers hope if nothing else. Right now, hope would be a good thing.

Posted by barbh on 15 Jan 09 09:31 AM EST
I like carolr am the mother of a 41 year old father of five who is an alcoholic and he has tried to break the addiction many times. I would like to see standardized studies done on this baclofen treatment in areas all across this country. My son is a descendant of a bad alcoholic and also has cousins on this side of the family who apparently have inherited the addiction gene. He would like to be able to break this addiction but does not seem to have the wherewithall to do it himself. It would be a godsend to the family to get it cleared for use.

Posted by C. Wallen on 15 Jan 09 11:18 AM EST
I have a daughter who needs help with her addictions and know I she will die soon if she doesn't stop. She is only 35 and has been drinking since 12 or 13. Many hospital stays recently. I would do this in a heartbeat if it just might save her life. Thanks, CW

Posted by Georgia in Nashville on 09 Feb 09 01:28 AM EST
We will be looking for a doctor to prescribe baclofen in the morning. My husband is a great man who has suffered with this disease far too long w/o an effective treatment. He regualarly attends AA. He has been to 2 treatment ctrs (insurance did not cover either). He has tried Naltexone, Campral, Antabuse, and prison. At 44, he considers suicide an option. No amount of love, compassion, patience, or understanding helps when the craving hits. He has good, smart, loving children and a wife who adores him. He has the best sponsors and support group. However, nothing helps, long-term, when the anxiety and depression takes over and then the craving to drink follows. To "alexgb": every drug has its potential side effects. That is why you should always be under the care of a competent doctor! My husband does NOT want to drink AT ALL. This is not about finding a way to drink "moderately"! For people with this disease and the families who love them, it is a nightmare."Not drinking" is only PART of the recovery process. There is no "cure" for this disease. To all the families who know the pain that this disease brings to your home ..I hope you find peace.

Posted by JWH on 12 Feb 09 08:14 PM EST
Baclofen has been proven to alieviate both alcohol craving and comorbid anxiety in several alcohol dependent subjects over the last few years, and IMO, further research should be conducted immediately. Baclofen has been proven to be a safe drug without notable side effects even in daily high doses of 270 mg in MS patients for over forty years. I wish to emphasize again, I don't believe it's a cure, but I do think it's a step in the right direction. I found Dr. Ameisen's book very inspiring, and with this newfound hope, I am determined to try Baclofen myself, regardless of the cost. It has worked for him and several others, so it may just work for me as well. Just my two cents worth...

Posted by Kelly on 20 Feb 09 12:29 PM EST
I'm dieing (literally and metaphoriccally). I been to treatment 4 times. longest sobriety, 1.5 years. I've taken Toprimate. It had NO effect on addiction and craving. I was taken off of it because it lowered my white-cell count to dangerous numbers. If there truly IS Some other medication that may help me and others...It turly IS worth trying. How much worse can the effects be compared to what alcohol does to an individual, families, friends, jobs, neighbors, strangers, children, and society in general. In MY case; AA, Treatment, sponsorship, does not work for me. PLEASE I BEG OF SOMEONE OUT THERE TO MAKE THIS POSSIBLE FOR ME AND MANY OTHERS.

Posted by Tess on 11 Mar 09 08:12 AM EDT
I pray this drug works, and becomes readily available to people who need it, and have tried everything else. So many families are suffering the effects of this family disease please please someone help us.

Posted by Judy on 23 Mar 09 02:33 AM EDT
My much loved big brother committed suicide while in rehab for cocaine addiction. His shame & remorse seemed insurmountable & I would give anything to have found a way to help him & he would have tried anything to be able to be the dad he wanted to be to his children. He did not deserve to die. They used to believe that ulcers were caused by stress & "type A" personalities, now it is known that it is caused by Helicobacter pylori infection & is cured by a "pill". Closed minds help no-one. Have some compassion.

Posted by Terry on 29 Mar 09 05:52 PM EDT
The current working theory postulates that baclofen acts through the GABA-b receptor to eliminate drug cravings. The only other substance known to act on this receptor is GHB, which occurs naturally in the body. If in fact a GHB deficiency is the root cause of alcoholic behaviors, this sounds like a disease to me. One study of baclofen efficacy showed a 70% rate of abstinence which is unheard of in studies of other (currently accepted) therapies. These results and common sense dictate that sound clinical trials should be conducted soon. Given current societal costs, delay would be unconsionable. I have read that such a trial would cost $500,000. Drug companies have no incentive because baclofen is out of patent. Government agencies are currently uninterested. This much can be raised easily through the internet and a study funded privately. I would be interested in working with others to make this happen. I am alcohol dependent, although at the low end of the range in published studies. I am investigating how I can obtain and test baclofen myself, hopefully it will not be difficult to find a physician to oversee the process. I'm confident that I will succeed.

Posted by Kay on 31 Mar 09 04:59 PM EDT
I have been on baclofen for 2 months now. It is nothing short of a miracle for me. Suffered under alcohol for 20+ years. Rehab twice. Had 1 yr sober then relapsed. FINALLY - I found baclofen looking for answers & my doctor let me try it. I HAVE BECOME COMPLETELY INDIFFERENT toward alcohol/drugs. IT HAS SAVED MY LIFE. If you are suffering, talk to your doctor. I take 120mg/day. The anxiety is manageable & I have hope for long term successful recovery. But - I am hearing conflicting reports if this drug is addicting or not. I would like to have input on this.

Posted by Kay on 02 Apr 09 09:31 AM EDT
However, I do not agree w/ 1 thing Dr. Ameisen says. He says he can go out and have an occasional drink. After what I have seen alcohol do to me and my family, I would NEVER even take 1 sip. And w/ baclofen on board, I have not even been tempted. Not 1 single time.

Posted by JWH on 25 Apr 09 02:16 AM EDT
I too have suffered from alcoholism/addiction for over 20 years and have been to treatment twice. Anxiety, preoccupation, and cravings always interfered with my sobriety. I tried FDA approved meds but they did nothing to suppress cravings. I've been taking Baclofen for just under a month and have become completely indifferent to alcohol. For the first time in decades I am free from it's grasp, it's amazing! I haven't so much as even thought about drinking for two weeks and it's very liberating. My gratitude cannot be expressed with words. I also disagree with having an occasional drink as it defeats the whole point. To my knowledge, Baclofen is non-addictive. But like other meds, dosage does require tapering down to prevent withdrawl symptoms if one chooses to cease treatment. At my current maintenance dose (120 mg. daily), I have no side effects.

Posted by Kay on 26 Apr 09 07:32 PM EDT
If anyone wants to discuss baclofen - please feel free to email me at k8tee1@gmail.com

Posted by Tonya on 04 May 09 10:41 PM EDT
I'm wondering if this drug could be used to treat marijuana abuse. I'm also wondering if Baclofen is in any way addictive itself. How can I find out?

Posted by JWH on 21 Jun 09 06:40 PM EDT
You could do an internet search specific to your questions e.g. "Baclofen+marijuana craving" or "Baclofen+addictive qualities" or something similar. Wikipedia's entry for Baclofen is a good source for information last time I checked, and Dr. Ameisen's FAQ page answers several questions... including whether Baclofen is addictive or not: http://www.olivierameisen.com/en/faq Baclofen works by correcting imbalances of neurotransmission in the brain via the GABA-B receptor which is linked with the brain's reward system. It's believed that these imbalances are the source of addictive and compulsive behaviors, as well as anxiety and depression. The only other substance known to have similar results on the brain's neurotransmission is GABA. GABA however, is addictive while Baclofen is not. Though I have not seen it mentioned specifically, compulsion to ingest THC is certain to be suppressed with Baclofen therapy as well. However, other factors such as the culture that goes along with it will probably need to be abandoned for success. One thing I'll attest to is this, there needs to be an earnest desire among the patient to quit the substance/behavior before commencing with Baclofen therapy to ensure it's success. Without it, they are certain to fail.

Posted by Jason on 30 Jun 09 06:06 PM EDT
I have been on baclofen for 3 years. I will say that it was the ONLY thing that curved my Vicodin withdrawals. Because of baclofen, I no longer take vicodin. Baclofen makes me feel normal without that "high" feeling that I got on vicodin. It is so much better to walk around being able to function normally! The only downside to baclofen for me is sometimes if I take more than 20 milligrams a day, I do breathe a lot heavier. Also, if I don't drink 3 glasses of water a day, sometimes it will create MORE back pain. No stomach pains, dizziness, insomnia or anything like that though.

Posted by nanb on 21 Jul 09 12:09 PM EDT
Please, I need a dr in Montana - does anyone know the name of the neurologist mentioned in Dr. A's book. If you can provide the name I thank from the bottom of my heart -- I am a mother of someone who desperately needs this help.

Posted by Bac Supporter on 25 Aug 09 03:40 PM EDT
I've tried everything in the past Naltrexone, topamirate, campral, antabuse(dangerous drug BTW), yoga, meditation, hypnosis...anything and everything and nothing has worked. I've been taking Baclofen for two weeks now and I am titrating the dosage slowly. I have already experienced lessened anxiety, a huge reduction in cravings and a total sense of hope and wellbeing. There needs to be more trials done for this drug. This drug needs to be an accepted method of treatment for addiction. People are dying everyday due to alcohol and suicide related to alcohol addiction. I'm sure given the choice, the addicted person with severe depression and suicidal thoughts would risk the side effects, which are mild in comparison. For all of those that are skeptics, please read Dr. A's book.

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