Androstenedione is produced naturally in humans during the production of testosterone and estrogen. However, once andro is metabolized by the body, it acts like a steroid and poses similar health risks.

Many products containing andro are marketed as dietary supplements that enhance athletic performance.

"Young people, athletes and other consumers should steer clear of andro because there are serious, substantial concerns about its safety," said HHS Secretary Tommy Thompson. "Young people should understand that there are no shortcuts to a stronger body, and that the best way to get faster and stronger is through good diet, nutrition, and exercise."

The FDA has sent warning letters to 23 companies ordering them to stop distribution of products sold as dietary supplements that contain androstenedione. The companies were also notified that they could face enforcement action.

"While andro products may seem to have short-term benefits, the science shows that these same properties create real and significant health risks," said FDA Commissioner Mark McClellan, Ph.D., M.D. "While the products are advertised to athletes, they have the potential to get into the hands of our impressionable youth who may believe these products will help their development. Anyone who takes these products in sufficient quantities to build muscle or improve performance is putting himself or herself at risk for serious long-term and potentially irreversible health consequences. There is no proven safe substitute for hard work and training when it comes to improving athletic skill; we will do all we can to protect Americans against companies that seek to profit by trying to convince consumers otherwise."

As part of the crackdown, Thompson urged Congress to pass legislation that would classify andro-containing products as controlled substances.

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